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"Safe Mode" is a special setting in Windows operating systems that runs with a minimum set of extensions and services. Because it is running with fewer features enabled, Windows will perform much faster, and is less vulnerable to attack. For these reasons, Safe Mode is the optimal setting for performing any sort of virus-related troubleshooting.

In order to boot your Windows computer into Safe Mode, restart your computer, and when the screen turns black, begin tapping the F8 key on the top of your keyboard. Do this repeatedly every second or so, until you're presented with a screen of system startup options. In Windows XP, you'll be presented with options for "Safe Mode with Networking," and "Safe Mode without Networking." Be certain to select the network-free option. Because the network drivers for the system will not be enabled, the viruses and spyware on the machine will be unable to function, and often unable to hide or defend themselves while you scan for them.

Also, because the system is running light, it'll run fast. This will speed up your antivirus and antispyware scans considerably.